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Monitoring of the proportion of immune individuals and the effectiveness of vaccination in a population involves evaluation of several important parameters, including the level of virus-neutralising antibodies. In order to combat the COVID-19 pandemic, it is essential to develop approaches to detecting SARS-CoV-2 neutralising antibodies by safe, simple and rapid methods that do not require live viruses. To develop a test system for enzyme-linked immunosorbent assay (ELISA) that detects potential neutralising antibodies, it is necessary to obtain a highly purified recombinant receptor-binding domain (RBD) of the spike (S) protein with high avidity for specific antibodies. The aim of the study was to obtain and characterise a SARSCoV-2 S-protein RBD homodimer and a recombinant RBD-expressing cell line, as well as to create an ELISA system for detecting potential neutralising antibodies. Material(s) and Method(s): the genetic construct was designed in silico. To generate a stable producer cell line, the authors transfected CHO-S cells, subjected them to antibiotic pressure, and selected the optimal clone. To isolate monomeric and homodimeric RBD forms, the authors purified the recombinant RBD by chromatographic methods. Further, they analysed the activity of the RBD forms by Western blotting, bio-layer interferometry, and indirect ELISA. The analysis involved monoclonal antibodies GamXRH19, GamP2C5, and h6g3, as well as serum samples from volunteers vaccinated with Gam-COVID-Vac (Sputnik V) and unvaccinated ones. Result(s): the authors produced the CHO-S cell line for stable expression of the recombinant SARS-CoV-2 S-protein RBD. The study demonstrated the recombinant RBD's ability to homodimerise after fed-batch cultivation of the cell line for more than 7 days due to the presence of unpaired cysteines. The purified recombinant RBD yield from culture broth was 30-50 mg/L. Monomeric and homodimeric RBD forms were separated using gel-filtration chromatography and characterised by their ability to interact with specific monoclonal antibodies, as well as with serum samples from vaccinated volunteers. The homodimeric recombinant RBD showed increased avidity for both monoclonal and immune sera antibodies. Conclusion(s): the homodimeric recombinant RBD may be more preferable for the analysis of levels of antibodies to the receptor-binding domain of the SARS-CoV-2 S protein.Copyright © 2023 Authors. All rights reserved.
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Touch-enabled sensation and actuation are expected to be the most promising, straightforward, and important uses of the B5G/6G communication networks. In light of the next generation (6G) systems' prerequisite for low latency, the infrastructure should be reconfigurable, intelligent, and interoperable in the real-time existing wireless network. It has a drastic impact on society due to its high precision, accuracy, reliability, and efficiency, combined with the ability to connect a user from remote areas. Hence, the touch-enabled interaction is primarily concerned with the real-time transmission of tactile-based haptic information over the internet, in addition to the usual audio, visual, and data traffic, thus enabling a paradigm shift towards a real-time control and steering communication system. The existing system latency and overhead often have delays and limitations on the application's usability. In light of the aforementioned concerns, the study proposes an intelligent touch-enabled system for B5G/6G and an IoT-based wireless communication network, incorporating AR/VR technologies. The tactile internet and network-slicing serve as the backbone of touch technology and incorporates intelligence from techniques such as artificial intelligence and machine/deep learning. The survey also introduces a layered and interfacing architecture with its E2E solution for the intelligent touch-based wireless communication system. It is anticipated for the upcoming 6G system to provide numerous opportunities for various sectors to utilize AR/VR technology in robotics and healthcare facilities to help in addressing several problems faced by society. Conclusively the article presents a few use cases concerning the deployment of touch infrastructure in automation, robotics, and intelligent healthcare systems, assisting in the diagnosis and treatment of the prevailing Covid-19 cases. The paper concludes with some considerable future research aspects of the proposed system with a few ongoing projects concerning the development and incorporation of the 6G wireless communication system.
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Following the COVID-19 outbreak, the health sector is undergoing a deep transformation that is increasingly pushing it towards the exploitation of technology, thus fostering the growth of digital health (eHealth). Cellular networks play a pivotal role in promoting the digitalization of healthcare, and researchers are banking on beyond fifth-generation (B5G) and sixth-generation (6G) technologies to reach the turning point, given that, according to forecasts, 5G will not be able to meet future expectations. Security is an aspect that definitely should not be overlooked for the success of eHealth to occur. This work aims to address the security issue from a poorly explored viewpoint, namely that of economics. In this paper, we first describe the main eHealth services, highlighting the key stakeholders involved. Then, we discuss how next-generation technologies could support these services to identify possible business relationships and, therefore, to realize an innovative business-oriented security analysis. A qualitative assessment of the impact of specific security breaches in diverse business conditions is provided. Moreover, we examine a case study in order to show the effects of security attacks in a definite scenario and discuss their impact on business dynamics.
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The Metaverse allows the integration of physical and digital versions of users, processes, and environments where entities communicate, transact, and socialize. With the shift towards Extended Reality (XR) technologies, the Metaverse is envisioned to support a wide range of applicative verticals. It will support a seamless mix of physical and virtual worlds (realities) and, thus, will be a game changer for the Future Internet, built on the Semantic Web framework. The Metaverse will be ably assisted by the convergence of emerging wireless communication networks (such as Fifth-Generation and Beyond networks) or Sixth-Generation (6G) networks, Blockchain (BC), Web 3.0, Artificial Intelligence (AI), and Non-Fungible Tokens (NFTs). It has the potential for convergence in diverse industrial applications such as digital twins, telehealth care, connected vehicles, virtual education, social networks, and financial applications. Recent studies on the Metaverse have focused on explaining its key components, but a systematic study of the Metaverse in terms of industrial applications has not yet been performed. Owing to this gap, this survey presents the salient features and assistive Metaverse technologies. We discuss a high-level and generic Metaverse framework for modern industrial cyberspace and discuss the potential challenges and future directions of the Metaverse's realization. A case study on Metaverse-assisted Real Estate Management (REM) is presented, where the Metaverse governs a Buyer–Broker–Seller (BBS) architecture for land registrations. We discuss the performance evaluation of the current land registration ecosystem in terms of cost evaluation, trust probability, and mining cost on the BC network. The obtained results show the viability of the Metaverse in REM setups.
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Research and development at NTT Network Innovation Laboratories aims to establish elemental technologies for next-generation communication networks envisioned under NTT's Innovative Optical and Wireless Network (IOWN) and the 6th-generation mobile communication system (6G). These technologies, which include advanced and high-capacity backbone optical transmission networks and extended coverage of wireless communications, are being developed to support dramatic changes in the information society such as the expansion of remote work due to the COVID-19 pandemic. This article introduces optical/wireless transmission technologies and systemization technologies currently being researched and developed at NTT Network Innovation Laboratories. © 2022 Authors. All rights reserved.
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Recently, unmanned aerial vehicles (UAVs) are deployed in Novel Coronavirus Disease-2019 (COVID-19) vaccine distribution process. To address issues of fake vaccine distribution, real-time massive UAV monitoring and control at nodal centers (NCs), the authors propose SanJeeVni, a blockchain (BC)-assisted UAV vaccine distribution at the backdrop of sixth-generation (6G) enhanced ultra-reliable low latency communication (6G-eRLLC) communication. The scheme considers user registration, vaccine request, and distribution through a public Solana BC setup, which assures a scalable transaction rate. Based on vaccine requests at production setups, UAV swarms are triggered with vaccine delivery to NCs. An intelligent edge offloading scheme is proposed to support UAV coordinates and routing path setups. The scheme is compared against fifth-generation (5G) uRLLC communication. In the simulation, we achieve and 86% improvement in service latency, 12.2% energy reduction of UAV with 76.25% more UAV coverage in 6G-eRLLC, and a significant improvement of [Formula: see text]% in storage cost against the Ethereum network, which indicates the scheme efficacy in practical setups.
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As the technical specifications of the 5th Generation (5G) wireless communication standard are being wrapped up, there are growing efforts amongst researchers, industrialists, and standardisation bodies on the enabling technologies of a 6G standard or the so-called Beyond 5G (B5G) one. Although the 5G standard has presented several benefits, there are still some limitations within it. Such limitations have motivated the setting up of study groups to determine suitable technologies that should operate in the year 2030 and beyond, i.e., after 5G. Consequently, this Special Issue of Future Internet concerning what possibilities lie ahead for a 6G wireless network includes four high-quality research papers (three of which are review papers with over 412 referred sources and one regular research). This editorial piece summarises the major contributions of the articles and the Special Issue, outlining future directions for new research.
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Over the past two years, the spread of COVID-19 has spurred the use of information and communication technologies (ICT) in aid of healthcare. The need to guarantee continuity to care has promoted research and industry activities aimed at developing solutions for the digitalization of the procedures to be performed to provide health services, even in emergency scenarios. Digital collection, transmission, and processing of health data represent the starting point for fulfilling this innovation process but also bring heterogeneous challenges. These motivations led to the elaboration of this work, which analyzes innovative and technological tools for the development of digital health (eHealth) through the collection of multisectoral literature, produced thanks to the cooperation of varied research groups, thus providing a multidisciplinary survey. Since digital health is expected to be one of the leading applications of the sixth-generation (6G) wireless cellular networks, this paper covers the related telecommunications aspects. Furthermore, the exploitation of artificial intelligence paradigms to elaborate massive amounts of biological data is examined. Given the extreme sensitivity of health data, this paper also investigates security and privacy issues. In particular, the main techniques and approaches to guarantee security properties (i.e., anonymity, responsibility, authentication, confidentiality, integrity, non-repudiation, and revocability) are studied. Applications involving innovative electromagnetic systems for healthcare and assisted living services are described to provide an example of an eHealth scenario leveraging ICT. Finally, the telemedicine-related regulations of the European Commission are analyzed, with particular reference to the General Data Protection Regulation (GDPR).
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With the online-everything transformation accelerated by a global Covid-19 pandemic, we may finally find ourselves on the verge of the next potentially paradigm-shifting step after the mobile Internet: The Metaverse. Among others, the Metaverse will utilize head-mounted devices (HMDs) and extended reality (XR), including but not limited to virtual and augmented reality (VR/AR), as the medium to connect avatars and users in the real world. In addition, the Metaverse is supposed to provide gamified experiences around emerging Web 3.0 technologies and is anticipated to be the precursor of the so-called Multiverse, which will serve as an architecture of advanced XR experience realms. In this paper, we focus on the anticipated 6G post-smartphone era, where smart wearables such as VR/AR HMDs are increasingly replacing the functionalities of smartphones. Our contributions are threefold: (i) we first extend Metaverse's primary focus on VR/AR to Multiverse's advanced XR realms of experience. Next, we gamify and implement all eight Multiverse realms of experience using Oculus Quest 2 and Microsoft HoloLens 2 as state-of-the-art VR/AR HMDs, experimentally investigating and comparing the performance of a (ii) single-player origami game and (iii) multi-player maze game across our proposed integrated VR/AR HMD and Amazon Mechanical Turk crowd-of-Oz (CoZ) platform.
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Digital health (eHealth) represents the future of the healthcare sector. Although the digitalization of services and processes related to the health sphere has been coveted for a long time, the emergency caused by COVID-19 has marked a turning point in this sense. The fifth generation (5G) network paradigms are good candidates to meet some of the current requirements of eHealth services, however, researchers are already projected towards sixth generation (6G) and are working on proposals on how breakthrough trends and technologies can improve performance in health data communication and processing. It is worth emphasizing that, in the management of such sensitive data, security and trustworthiness of devices involved in the network cannot in any way be underestimated. On the basis of these considerations, this paper proposes an innovative trust model for the selection of the Internet of Medical Things (IoMT) devices responsible for transmitting health data. The data possibly detected and transmitted by medical sensors often includes multimedia data, such as the lung sound detected on a remotely monitored patient with COVID-19. This paper also provides a collection of works of literature that propose trust-based solutions for the security of eHealth services in order to illustrate the current state of the art in which the proposed model fits. © 2022 IEEE.
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The 6th Generation of wireless communication, 6G, is the future of wireless communication technology. 6G has the potential to support various pioneering applications. Post Covid-19 pandemic, the necessity of remote data-connectivity is recognized as a socio-economic requirement. Data-centric communication has been one of the key-features in 5G and the trend is expected to continue in near future. 6G proposes to support various cutting-edge applications, including remote healthcare, holographic transportation, twin body area network, unmanned vehicle, smart infrastructures and augmented and virtual reality. These applications require a superior data-rate and infrastructure beyond the current 5G facilities. Hence, currently, both industry and academia are exploring the possible technology solutions that can support the advanced communication requirements of near future. This research work intends to provide a comprehensive summary of the Key Performance Indicators (KPI) of 6G, possible 6G network architectures, use cases and enabling technologies. Additionally, an extensive summary of the Machine Learning (ML) algorithms implemented in 6G are provided to achieve various technology goals. © 2022 IEEE.
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Remote health care is currently one of the most promising solutions to ensure a high level of treatment outcome, cost-efficiency and sustainability of the healthcare systems worldwide. Even though research on remote health care can be traced back to the early days of the Internet, the recent COVID-19 has necessitated further improvement in existing health care systems with invigorated research on remote health care technologies. In this article we delve into the state-of-the-art research in latest technologies and technological paradigms that play a vital role in enabling the next generation remote health care and assisted living. First the need of using the latest technological developments in the domain of remote health care is briefly discussed. Then the most important technologies and technological paradigms that are crucial in enabling remote health care and assisted living are emphasised. Henceforth, a detailed survey of existing technologies, potential challenges in those technologies, and possible solutions is conducted. Finally, missing research gaps and important future research directions in each enabling technology are brought forth to motivate further research in remote health care.
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A digital replica of any physical system or process is referred to as a digital twin (DT). In general, a DT is a software program that accepts real-world data of a physical system at ground level as inputs and creates useful outputs in the form of insights. At the moment, the manufacturing industry and business are concentrating their efforts on this technology. Due to the outbreak of COVID-19, the entire globe has turned to virtual meetings and live video interactions in various fields as health care, business, and education. We explore the most recent viewpoints and future technology trends that are most likely to drive DT in this study. The incorporation of blockchain in DT will allow the network to efficiently monitor and manage resource consumption and sharing. The idea of a digital twin of a smart city is presented in this article. Smart city development aims to enhance not just the city's overall performance, but also its basic infrastructure, procedures, and facilities, as well as its socioeconomic wellbeing. In order to strengthen security and privacy in smart cities, we examine how security may influence the DT. We offer a complete analysis of blockchain-based DT in this article. Overall, our study aims to give insightful direction for digital twin security and privacy research. © 2022, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.
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BACKGROUND: The dementia epidemic is progressing fast. As the world's older population keeps skyrocketing, the traditional incompetent, time-consuming, and laborious interventions are becoming increasingly insufficient to address dementia patients' health care needs. This is particularly true amid COVID-19. Instead, efficient, cost-effective, and technology-based strategies, such as sixth-generation communication solutions (6G) and artificial intelligence (AI)-empowered health solutions, might be the key to successfully managing the dementia epidemic until a cure becomes available. However, while 6G and AI technologies hold great promise, no research has examined how 6G and AI applications can effectively and efficiently address dementia patients' health care needs and improve their quality of life. OBJECTIVE: This study aims to investigate ways in which 6G and AI technologies could elevate dementia care to address this study gap. METHODS: A literature review was conducted in databases such as PubMed, Scopus, and PsycINFO. The search focused on three themes: dementia, 6G, and AI technologies. The initial search was conducted on April 25, 2021, complemented by relevant articles identified via a follow-up search on November 11, 2021, and Google Scholar alerts. RESULTS: The findings of the study were analyzed in terms of the interplay between people with dementia's unique health challenges and the promising capabilities of health technologies, with in-depth and comprehensive analyses of advanced technology-based solutions that could address key dementia care needs, ranging from impairments in memory (eg, Egocentric Live 4D Perception), speech (eg, Project Relate), motor (eg, Avatar Robot Café), cognitive (eg, Affectiva), to social interactions (eg, social robots). CONCLUSIONS: To live is to grow old. Yet dementia is neither a proper way to live nor a natural aging process. By identifying advanced health solutions powered by 6G and AI opportunities, our study sheds light on the imperative of leveraging the potential of advanced technologies to elevate dementia patients' will to live, enrich their daily activities, and help them engage in societies across shapes and forms.
Subject(s)
COVID-19 , Dementia , Artificial Intelligence , Dementia/psychology , Dementia/therapy , Humans , Quality of Life , TechnologyABSTRACT
This paper presents a review on the state-of-the-art of 'Stealth Communication' (SC), focused on potential applications in 5G/6G. SC is a new wireless system aimed at enhancing spectral efficiency and cybersecurity/privacy based on employing Ultra-Wide-Band (UWB) RF signals that mimic noises in wave form and below-noise-level at the receiver frontend. For 5G/6G applications, Same Frequency (SF) Simultaneous Transmit and Receive (STAR) operating bandwidth covering 400 MHz to 11 GHz, and their Technology Readiness Level, are discussed. Implementation of SC in 5G/6G, held back so far by high costs and Covid-19, should be able to gain enough momentum under the thrusts of rising cyber attacks in 2021. © 2021 IEEE.
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The '15-minute city' concept is emerging as a potent urban regeneration model in post-pandemic cities, offering new vantage points on liveability and urban health. While the concept is primarily geared towards rethinking urban morphologies, it can be furthered via the adoption of Smart Cities network technologies to provide tailored pathways to respond to contextualised challenges through the advent of data mining and processing to better inform urban decision-making processes. We argue that the '15-minute city' concept can value-add from Smart City network technologies in particular through Digital Twins, Internet of Things (IoT), and 6G. The data gathered by these technologies, and processed via Machine Learning techniques, can unveil new patterns to understand the characteristics of urban fabrics. Collectively, those dimensions, unpacked to support the '15-minute city' concept, can provide new opportunities to redefine agendas to better respond to economic and societal needs as well as align more closely with environmental commitments, including the United Nations' Sustainable Development Goal 11 and the New Urban Agenda. This perspective paper presents new sets of opportunities for cities arguing that these new connectivities should be explored now so that appropriate protocols can be devised and so that urban agendas can be recalibrated to prepare for upcoming technology advances, opening new pathways for urban regeneration and resilience crafting.
Subject(s)
Internet of Things , Cities , Machine Learning , Technology , Urban HealthABSTRACT
Touch enabled sensation and actuation is expected to be one of the most promising, straightforward and important uses of the next generation communication networks. In light of the next generation (B5G/6G) system’s need for low latency, the infrastructure should be reconfigurable and intelligent in order to be able to work in real time and interoperable with the existing wireless network. It has a drastic impact on the society due to its high precision, accuracy, reliability and efficiency as well as the ability to connect a user from far away or remote areas. Such a touch-enabled interaction is primarily concerned with the real time transmission of the tactile based haptic information over the internet, in addition to the usual audio, visual and data traffic, thus enabling a paradigm shift towards establishing a real time control and steering communication system. Due to the existing system’s latency and overhead, it creates delays and limits the usability of the future applications. In light of the aforementioned concerns, this study proposes an intelligent touch-enabled system for B5G/6G and IoT based wireless communication network that incorporates the AR/VR technologies. The tactile internet and network slicing serve as the backbone of the touch technology which incorporates intelligence from techniques such as artificial intelligence and machine/deep learning. The survey also introduces a layered and interfacing architecture complete with its E2E solution for the intelligent touch based wireless communication system. It is anticipated for the next generation system to provide numerous opportunities for various sectors utilizing AR/VR technology in robotics and healthcare facilities, all with the intension of helping in addressing severe problems faced by the society. Conclusively the article presents a few use cases concerning the deployment of touch infrastructure in automation and robotics as well as in intelligent healthcare systems, assisting in the diagnosis and treatment of the prevailing covid-19 cases. The paper concludes with some considerable future research aspects of the proposed system with few of the ongoing projects pertaining to the development in the incorporation of the next generation (6G) system. Author
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The COVID-19 pandemic has changed the world. Today, the use of Information and Communications Technology (ICT) in support of education, medicine, business and administration has become a reality practically everywhere. In particular, the eHealth (digital Health) sector is on the cusp of a revolution, fueled by the worldwide health emergency due to the spread of the new coronavirus. With a view to developing new sixth generation (6G)-oriented architectures, advanced eHealth services like telemonitoring would benefit from the support of technologies that guarantee secure data access, ultra-low latency and very-high reliability targets, which are hardly achievable by the fifth generation (5G). This is the reason why this work proposes an eHealth system architecture, in which low-latency enabling technologies like Device-to-Device (D2D) communications and Multi-access Edge Computing (MEC) are integrated and supported by security mechanisms for an optimal management of sensitive health data collected by Internet of Medical Things (IoMT) devices. A preliminary evaluation of the proposed framework is provided that shows promising results in terms of data security and latency reduction. IEEE
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Ever increasing demands of data traffic makes the transition to 6G communications in the 300 GHz band inevitable. Short-channel field-effect transistors (FETs) have demonstrated excellent potential for detection and generation of terahertz (THz) and sub-THz radiation. Such transistors (often referred to as TeraFETs) include short-channel silicon complementary metal oxide (CMOS). The ballistic and quasi-ballistic electron transport in the TeraFET channels determine the TeraFET response at the sub-THz and THz frequencies. TeraFET arrays could form plasmonic crystals with nanoscale unit cells smaller or comparable to the electron mean free path but with the overall dimensions comparable with the radiation wavelength. Such plasmonic crystals have a potential of supporting the transition to 6G communications. The oscillations of the electron density (plasma waves) in the FET channels determine the phase relations between the unit cells of a FET plasmonic crystal. Excited by the impinging radiation and rectified by the device nonlinearities, the plasma waves could detect both the radiation intensity and the phase enabling the line-of-sight terahertz (THz) detection, spectrometry, amplification, and generation for 6G communication.
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This paper prosed a novel 6G QoS over the future 6G wireless architecture to offer excellent Quality of Service (QoS) for the next generation of digital TV beyond 2030. During the last 20 years, the way society used to watch and consume TV and Cinema has changed radically. The creation of the Over The Top content platforms based on Cloud Services followed by its commercial video consumption model, offering flexibility for subscribers such as n Video on Demand. Besides the new business model created, the network infrastructure and wireless technologies also permitted the streaming of high-quality TV and film formats such as High Definition, followed by the latest widespread TV standardization Ultra-High- Definition TV. Mobile Broadband services onset the possibility for consumers to watch TV or Video content anywhere at any time. However, the network infrastructure needs continuous improvement, primarily when crises, like the coronavirus disease (COVID-19) and the worldwide pandemic, creates immense network traffic congestions. The outcome of that congestion was the decrease of QoS for such multimedia services, impacting the user's experience. More power-hungry video applications are commencing to test the networks' resilience and future roadmap of 5G and Beyond 5G (B5G). For this, 6G architecture planning must be focused on offering the ultimate QoS for prosumers beyond 2030.